Red Cell Controls
Globulin may bind in vivo or in vitro to erythrocytes (red blood cells). This may occur in Hemolytic Disease of the Fetus and Newborn (HDFN), in transfusion reactions, and in autoimmune hemolytic anemia. The DAT and the IAGT typically detects IgG or complement or both depending on the specificity of the Anti-Human Globulin (AHG) reagent used. It is important to use a control to confirm the efficacy of the AHG reagent used.
Hemo bioscience has received 510(k) clearance to manufacture complement control cells using a modified Fruitstone1 low ionic method. New lots are manufactured every 28 days and lot release is performed with a wide range of AHG reagents. Please contact us to receive information regarding pricing, shipping schedule and a sales brochure.
Hemo bioscience is also the exclusive distributor of the American Red Cross IgG Control Cells. These cells have been formulated with the ability to detect partial neutralization of the anti human globulin test. Other red cell products are currently under development.
| C3 Control Cells |
Complement coated control cells |
H9000 |
1 x 3mL |
| IgG Control Cells |
3-4% Red cells |
H9030 |
3 x 3mL |
| IgG Control Cells |
3-4% Red cells |
H9100 |
10 x 3mL |
Controlling the Coombs Test: Are Strong Reactions Better or Worse?
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1 Fruitstone MJ. C3b sensitized erythrocytes. Transfusion 1978;18:125